One of the big things I wanted to tackle with this model was how clothing is handled.

I really think Marvelous designer is great software, and it gives a result hand-sculpting really can't achieve.

for rendered  animations, I think characters will largely be animated as nude, and the clothes will be simulated entirely in marvelous.
but for realtime? I haven't figured that out yet... Marvelous designer meshes are too heavy for any realtime program.